Research Output
Schizophrenia and GABAA receptor subunit genes
  Alterations in 纬-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for the GABAA receptor 伪1, 伪2, 伪4, 伪5, 伪6, 尾1 and 尾3 subunit genes. Evidence of linkage was not found when assuming either autosomal dominant or autosomal recessive inheritance. The non-parametric sib pair test also did not reveal significant evidence of deviation from expected segregation ratios.

  • Type:

    Article

  • Date:

    31 December 1995

  • Publication Status:

    Published

  • Publisher

    Ovid Technologies (Wolters Kluwer Health)

  • DOI:

  • ISSN:

    0955-8829

  • Library of Congress:

    RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

  • Dewey Decimal Classification:

    616.8 Nervous & mental disorders

Citation

麻豆社区

Byerley, W., Bailey, M. E., Hicks, A. A., Riley, B. P., Darlison, M. G., Holik, J., 鈥oon, H. (1995). Schizophrenia and GABAA receptor subunit genes. Psychiatric Genetics, 5(1), 23-30. https://doi.org/10.1097/00041444-199521000-00004

Keywords

Schizophrenia, , Receptor Subunit Genes, Linkage analysis,

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