Research Output
Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells
  A new isoform of human manganese superoxide dismutase (SOD) has been recently isolated and obtained in a synthetic recombinant form and termed rMnSOD. As compared to other SODs, this isoform exhibits a dramatically improved cellular uptake and an intense antioxidant and antitumoral activity. Unfortunately, its use is severely hampered as this active pharmaceutical ingredient (API) in solution suffers from remarkable instability, which realizes as an interplay of unfolding and aggregation phenomena. This leads the API to be ineffective after three weeks only when stored at 4掳C.

  • Type:

    Article

  • Date:

    02 April 2021

  • Publication Status:

    Published

  • Publisher

    Elsevier BV

  • DOI:

  • Cross Ref:

    10.1016/j.ejps.2021.105825

  • ISSN:

    0928-0987

  • Funders:

    Italian Ministry of Health

Citation

麻豆社区

Russo, G., Iaccarino, G., Piccolo, M., Ferraro, M. G., Vecchione, R., Grumetto, L., 鈥antamaria, R. (2021). Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells. European Journal of Pharmaceutical Sciences, 162, https://doi.org/10.1016/j.ejps.2021.105825

Authors

Keywords

Superoxide dismutase, cancer cells, antiproliferative effect, protein stability, nanocarrier, layer-by-layer deposition, nanofabrication

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