Research Output
Genetic mapping of the mouse X chromosome in the region homologous to human Xq27鈥揦q28
  The four loci Gabra3, DXPas8, CamL1, and Bpa, located near the murine X-linked visual pigment gene (Rsup), have been ordered using 248 backcross progeny from an interspecific mating of (B6CBA-Aw-JA-Bpa) and Mus spretus. One hundred twenty backcross progeny have been analyzed at seven anchor loci spanning the X chromosome and form a regional mapping panel. An additional 128 progeny have been screened for recombination events between Cf-9 and Dmd. Eighteen recombinants between these loci have been detected in the 248 animals; all of the recombinants were screened at the other anchor loci to identify any double crossovers. Pedigree analysis using these recombinants strongly favors a gene order of (Cf-9)-Gabra3-(DXPas8, Bpa)-CamL1-(Rsvp, P3, Cf-8)-Dmd for the loci studied. Synteny with human Xq27鈥揦q28 is retained, although the relative order of some loci may differ between the two species.

  • Type:

    Article

  • Date:

    30 April 1991

  • Publication Status:

    Published

  • DOI:

  • Cross Ref:

    088875439190360Q

  • ISSN:

    0888-7543

  • Library of Congress:

    QH426 Genetics

  • Dewey Decimal Classification:

    576 Genetics & evolution

Citation

麻豆社区

Herman, G. E., Faust, C. J., Darlison, M. G., & Barnard, E. A. (1991). Genetic mapping of the mouse X chromosome in the region homologous to human Xq27鈥揦q28. Genomics, 9(4), 670-677. https://doi.org/10.1016/0888-7543%2891%2990360-q

Keywords

Genetics,

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