Research Output
Confirmation of the localization of the human GABAA receptor 伪1-subunit gene (GABRA1) to distal 5q by linkage analysis
  The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investigation as candidate loci for a number of neurological and psychiatric disorders. We report here a highly polymorphic (dC-dA)n repeat within the human 伪1-subunit gene (GABRA1). Typing of this marker in the Centre d'Etude du Polymorphisme Humain (CEPH) panel of families confirms the previous assignment of the GABRA1 locus to the distal portion of chromosome 5q by demonstrating linkage to the markers CRI-L45 (D5S61) (Zmax = 11.00, 胃max = 0.15), CRI-V1022 (D5S54) (Zmax = 7.25, 胃max = 0.20), and CRI-P148 (D5S72) (Zmax = 5.71, 胃max = 0.24).

  • Type:

    Article

  • Date:

    30 November 1992

  • Publication Status:

    Published

  • Publisher

    Elsevier BV

  • DOI:

  • Cross Ref:

    S0888754305801788

  • ISSN:

    0888-7543

  • Library of Congress:

    QH426 Genetics

  • Dewey Decimal Classification:

    576 Genetics & evolution

Citation

麻豆社区

Johnson, K. J., Sander, T., Hicks, A. A., van Marle, A., Janz, D., Mullan, M. J., 鈥arlison, M. G. (1992). Confirmation of the localization of the human GABAA receptor 伪1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics, 14(3), 745-748. https://doi.org/10.1016/s0888-7543%2805%2980178-8

Keywords

Genetics

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