Research Output
Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial
  INTRODUCTION: Results from the ACHIEVE trial suggest hearing intervention may not reduce 3-year cognitive decline in all older adults with hearing loss but may be beneficial in certain groups. This secondary analysis investigated if participants with multiple risk factors for cognitive decline received greater benefits.
METHODS: We used a sample of dementia-free participants (N=2,692) from the ARIC cohort to develop a predictive model for cognitive decline. The model was applied to baseline measures of ACHIEVE participants (N=977) to estimate predicted risk. We tested an interaction between predicted risk and randomization to hearing intervention or health education control.
RESULTS: Among ACHIEVE participants in the top quartile of predicted risk, 3-year cognitive decline in the hearing intervention was 61.6% (95% CI 33.7%, 94.1%) slower than the control.
DISCUSSION: The effect of hearing intervention on reducing 3-year cognitive decline was greatest among individuals with multiple baseline risk factors associated with faster cognitive decline.
Trial Registration: ClinicalTrials.gov Identifier: NCT03243422

  • Date:

    12 March 2025

  • Publication Status:

    Accepted

  • ISSN:

    1552-5260

  • Funders:

    National Institutes of Health

Citation

麻豆社区

Pike, J. R., Huang, A. R., Reed, N. S., Arnold, M., Chisolm, T., Couper, D., Deal, J. A., Glynn, N. W., Goman, A. M., Hayden, K. M., Mitchell, C. M., Pankow, J. S., Sanchez, V., Sullivan, K. J., Tan, N. S., Coresh, J., & Lin, F. R. (in press). Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial. Alzheimer's & Dementia: The Journal of the Alzheimer's Association,

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