Kasia Siemienowicz
kasia siemienowicz

Dr Kasia Siemienowicz BSc (Hons) MSc PhD AFHEA

Lecturer

Biography

Dr Kasia Siemienowicz is a Lecturer of Biomedical Science in the School of Applied Sciences at Âé¶¹ÉçÇø, Scotland, UK.

Kasia’s research focuses upon understanding how altered hormonal exposure during fetal life affects development and predisposition to adult disease, to ensure best lifelong health opportunities for our children and providing information regarding possible treatment routes.

Kasia has a BSc (Hons) in Biomedical Sciences from the Âé¶¹ÉçÇø and MSc by Research (with Distinction) in Reproductive Sciences from the University of Edinburgh. In 2013 she was awarded an MRC Studentship to study for her PhD in the lab of Prof. Colin Duncan at QMRI Centre for Reproductive Health, the University of Edinburgh. She was awarded her PhD in 2017 with a thesis examining causes and consequences of dysregulation in an ovine model of PCOS. Following on from her PhD she has worked as a Research Fellow in the laboratory of Prof. Mick Rae at Âé¶¹ÉçÇø and in the laboratory of Prof. Colin Duncan at the University of Edinburgh.

Kasia is a member of Âé¶¹ÉçÇø for Reproduction and Fertility, Royal Âé¶¹ÉçÇø of Biology, Endocrine Âé¶¹ÉçÇø, and Associate Fellow of the Higher Education Academy.

In the past years Kasia won two prestigious awards: Young Investigator Award from the European Âé¶¹ÉçÇø of Endocrinology (for her work on the role of the adipose tissue in the pathology of the Polycystic Ovary Syndrome (PCOS), and best postgraduate student prize from the Âé¶¹ÉçÇø of Reproduction and Fertility (for her research on mechanistic underpinnings of obesity in PCOS). She was also shortlisted as a finalist for the Scottish Universities Life Sciences Alliance (SULSA) Early Career Researcher Prize, which awards outstanding early career scientists whose work shows excellent potential to make impact in the field of life sciences. Kasia’s research on the nature of obesity in PCOS and its therapeutic amelioration was featured in the New Scientist magazine. Her research has also illuminated a number of potential novel therapeutic routes, and these are now the underpinnings of both publications and funding applications.

Themes

Research Areas

Esteem

Conference Organising Activity

  • Poster presentation: Sexual dimorphism in liver function using an ovine model: implications for health and disease
  • Poster presentation: Prenatal androgen exposure disturbs female liver phenotype in an ovine model of PCOS. Fertility 2020 Conference.
  • Poster Presentation: Fetal androgen excess determines adult male health via hepatic dysfunction and dyslipidaemia. Mechanisms and Evolution of Integrational Change Conference
  • Poster Presentation: Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. European Congress of Endocrinology.
  • Poster Presentation: Decreased hepatic detoxification potential in males - consequences of androgen excess in fetal life. European Congress of Endocrinology.
  • Oral Presentation: Impaired adipose function in PCOS – evidence that the primary abnormalities are in subcutaneous rather than visceral fat. European Congress of Endocrinology.
  • Chair of the SRF Annual Conference, Oral Communications
  • Oral Presentation: Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an Ovine Model of Polycystic Ovary Syndrome (PCOS). Âé¶¹ÉçÇø of Reproduction and Fertility.
  • Oral Presentation: Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure. Âé¶¹ÉçÇø of Reproduction and Fertility.
  • Poster Presentation: Altered adipocytes in an Ovine Model of Polycystic Ovary Syndrome (PCOS). Âé¶¹ÉçÇø for Endocrinology.
  • Poster Presentation: The pathophysiology of increased hepatic IGF-1 expression in an ovine model of polycystic ovary syndrome. European Âé¶¹ÉçÇø of Endocrinology.
  • Oral Presentation: Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. Âé¶¹ÉçÇø of Reproduction and Fertility.

 

External Examining/Validations

  • External examiner for Edge Hill University MRes student

 

Fellowships and Awards

  • Âé¶¹ÉçÇø Above and Beyond Research & Innovation Winner
  • European Âé¶¹ÉçÇø of Endocrinology Science Meeting Grant
  • Science Meeting Grant, European Âé¶¹ÉçÇø of Endocrinology
  • Young Investigator Award, European Âé¶¹ÉçÇø of Endocrinology
  • SRF Student Prize, Âé¶¹ÉçÇø for Reproduction and Fertility
  • BES Grant, Âé¶¹ÉçÇø for Endocrinology

 

Membership of Professional Body

  • Associate Fellow of Higher Education Academy
  • Member of Âé¶¹ÉçÇø for Endocrinology
  • Member of European Âé¶¹ÉçÇø of Endocrinology
  • Member of Âé¶¹ÉçÇø for Reproduction and Fertility

 

Date


15 results

Impaired adipose function in PCOS - evidence that the primary abnormalities are in subcutaneous rather than visceral fat

Presentation / Conference
Siemienowicz, K., Coukan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2016, May)
Impaired adipose function in PCOS - evidence that the primary abnormalities are in subcutaneous rather than visceral fat. Paper presented at European Congress of Endocrinology

Altered adipocytes in an ovine model of polycystic ovary syndrome

Presentation / Conference
Siemienowicz, K., Couckan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2015, November)
Altered adipocytes in an ovine model of polycystic ovary syndrome. Poster presented at Âé¶¹ÉçÇø for Endocrinology BES

Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure

Presentation / Conference
Siemienowicz, K., Rae, M., Lerner, A., Franks, S., & Duncan, C. (2015, July)
Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure. Paper presented at Âé¶¹ÉçÇø for Reproduction and Fertility Annual Conference
Polycystic ovary syndrome, a common endocrine condition affecting up to 10% of women of reproductive age, is associated with an increased risk of developing insulin resistance...

Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome

Presentation / Conference
Siemienowicz, K., Rae, M., & Duncan, C. (2014, September)
Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. Paper presented at Âé¶¹ÉçÇø for Reproduction and Fertility Annual Conference, Edinburgh

The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome

Presentation / Conference
Siemienowicz, K., Boswell, L., Carr, D., Mina, T., Connolly, F., Rae, M., & Duncan, C. (2014, May)
The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome. Poster presented at 16th European Congress of Endocrinology
Exposure of pregnant sheep to increased concentrations of testosterone during midgestation results in a PCOS-like condition in the female offspring that includes increased hep...

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